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Volatile anaesthetics reduce serum S100 concentrations in patients undergoing elective cardiac surgery

Wojciech Dabrowski1, Ziemowit Rzecki1, Jaroslaw Wosko1, Jadwiga Biernacka1, Edyta Kotlinska1, Marek Czajkowski2
1Department of Anaesthesiology, Intensive Therapy, Medical University of Lublin, Poland; 2Department of Cardiac Surgery, Medical University of Lublin, Poland
[Applied Cardiopulmonary Pathophysiology 14: 139-148, 2010]


Background: The effect of volatile anaesthetics on plasma S100 protein has not been well-documented in cardiac surgery patients. The aim of the study was to analyse the effect of sevoflurane or isoflurane anaesthesia on plasma S100 concentration in patients undergoing elective, uncomplicated coronary artery bypass graft surgery.
Methods: One hundred thirty seven patients were prospectively randomized and allocated into three groups: A patients, who didnt receive volatile anaesthetics, B who received sevoflurane and C who received isoflurane. S100 was measured during anaesthesia and postoperative days 1 and 2.
Results: In all patients, S100 increased during anaesthesia and at the postoperative day 1 and 2. In group A, S100 increased during anaesthesia and postoperative days 1 and 2 but in groups B and C only during anaesthesia. Plasma S100 concentrations were significantly higher in group A than in group B and C.
Conclusions: 1) cardiac surgery resulted in S100 elevation, 2) isoflurane and sevoflurane significantly reduced plasma S100 concentrations.

Key words: extracorporeal circulation, CABG, S100, sevoflurane, isoflurane

Correspondence address:
Wojciech Dabrowski, M.D., Ph.D.
Department of Anaesthesiology and
Intensive Therapy
Medical University of Lublin
Jaczewskiego 8
20-954 Lublin
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