Wojciech Dabrowski1, Ziemowit Rzecki1, Jaroslaw Wosko1, Jadwiga Biernacka1, Edyta Kotlinska1, Marek Czajkowski2
1Department of Anaesthesiology, Intensive Therapy, Medical University of Lublin, Poland; 2Department of Cardiac Surgery, Medical University of Lublin, Poland
[Applied Cardiopulmonary Pathophysiology 14: 139-148, 2010]
Background: The effect of volatile anaesthetics on plasma S100ß protein has not been well-documented in cardiac surgery patients. The aim of the study was to analyse the effect of sevoflurane or isoflurane anaesthesia on plasma S100ß concentration in patients undergoing elective, uncomplicated coronary artery bypass graft surgery.
Methods: One hundred thirty seven patients were prospectively randomized and allocated into three groups: A – patients, who didn’t receive volatile anaesthetics, B – who received sevoflurane and C – who received isoflurane. S100ß was measured during anaesthesia and postoperative days 1 and 2.
Results: In all patients, S100ß increased during anaesthesia and at the postoperative day 1 and 2. In group A, S100ß increased during anaesthesia and postoperative days 1 and 2 but in groups B and C only during anaesthesia. Plasma S100ß concentrations were significantly higher in group A than in group B and C.
Conclusions: 1) cardiac surgery resulted in S100ß elevation, 2) isoflurane and sevoflurane significantly reduced plasma S100ß concentrations.
Key words: extracorporeal circulation, CABG, S100ß, sevoflurane, isoflurane
Wojciech Dabrowski, M.D., Ph.D.
Department of Anaesthesiology and
Medical University of Lublin