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You are here: Back issues » acp-2011 » acp-3-2011 » 01_chandrashekaraiah

Effects of clonidine premedication on hemodynamic changes during laparoscopic cholecystectomy – A randomized control study

M. M. Chandrashekaraiah, M. Upadya, S. P. Jayachandran, M. Wali
[Applied Cardiopulmonary Pathophysiology 15: 91-98, 2011]


Purpose: Laparoscopic cholecystectomy is the treatment of choice for cholelithiasis. The pneumoperitoneum used for laparoscopic procedures leads to significant impairment of cardiopulmonary function.
Methods: This randomized double blind study started with institute ethics committee approval. Sixty ASA 1 and ASA 2 patients undergoing elective laparoscopic cholecystectomy with no cardiovascular co-morbidity were enrolled for the study and received either tab clonidine 150 mcg [group C-30] or placebo drug tab lorazepam 2mg [group L- 30] orally one hour before the induction. Heart rate, systolic blood pressure, diastolic pressure and mean arterial pressure were recorded. The data obtained was analyzed using student‘s-test, ANOVA and Chi-square test.
Results: There is significant reduction of heart rate (16.6003), systolic pressure (22.433) and mean arterial pressure (14.8) (p<0.001) in study group.
Conclusion: From our study we found that oral clonidine 150mcg can effectively counteract the cardiovascular changes induced by pneumoperitoneum.

Key words: clonidine, laparoscopy, heart rate, blood pressure

Correspondence address
Mahesh Madhugiri Chandrashekaraiah, M.D.
Junior Consultant
Department of Cardiothoracic Anesthesia 
M S Ramaiah-Narayana Hrudayalaya Hospital
M S R I T Post
New BEL Road
Bangalore Karnataka-560054
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